File:Structure analysis of Bolivians and Totonacs using a panel of 324 AIMs.png

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English: Structure analysis of Bolivians and Totonacs using a panel of 324 AIMs. a) New World ancestry is predicted for all Bolivians and Totonacs. A non-New World ancestry component is correctly distinguished in the ten Bolivians with European admixture. b) A subset of 173 AIMs present in the merged genome-wide data set (this study, [9] and [20]) identifies New World ancestry in other unrelated Native American populations and demonstrates transferability to other New World populations that were not used to ascertain the AIMs. c) 47 AIMs from Kosoy et al. present in the merged data.


The 324 markers accurately distinguished the Totonac and Bolivian samples from other populations in a population structure analysis. No Old World sample exceeded 14% inferred New World ancestry, while all non-admixed Bolivian and Totonac samples had at least 91% inferred New World ancestry (median = 98%). The admixture estimates in the ten admixed Bolivian samples using these 324 AIMs were correlated with estimates from 120,958 unlinked genome-wide SNPs (r = 0.96, p < 0.001).
Date Published: 20 May 2012
Source Watkins WS, Xing J, Huff C, et al. Genetic analysis of ancestry, admixture and selection in Bolivian and Totonac populations of the New World. BMC Genetics. 2012;13:39. doi:10.1186/1471-2156-13-39. http://bmcgenet.biomedcentral.com/articles/10.1186/1471-2156-13-39
Author W Scott Watkins, Jinchuan Xing, Chad Huff, David J Witherspoon, Yuhua Zhang, Ugo A Perego, Scott R Woodward and Lynn B Jorde
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Structure analysis
PCA plot
Major mtDNA and Y-chromosome haplogroups for Totonacs and Bolivians
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