File:Serpin activation by heparin.png
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Summary[edit]
| Description |
English: Some serpins are activated by cofactors. The the serpin antithrombin has an RCL (blue) where the P1 arginine (blue sticks) points inwards, preventing protease binding. Binding of heparin (green sticks) causes the P1 arginine residue to flip to an exposed position. The target protease (grey) then binds both the exposed P1 arginine as well as the heparin. The serpin then activates and heparin is released. (PDB: 2ANT, 1TB6, 1EZX) |
| Date | |
| Source | Own work |
| Author | Thomas Shafee |
| Other versions | For unannotated version, see File:Serpin activation by heparin (unannotated).png |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 11:37, 26 December 2015 | | 2,400 × 1,131 (991 KB) | Evolution and evolvability (talk | contribs) | unstructured RCL added |
| 13:33, 23 December 2015 |  | 2,400 × 1,140 (982 KB) | Evolution and evolvability (talk | contribs) | arrows other way up | |
| 12:54, 23 December 2015 |  | 2,400 × 1,140 (981 KB) | Evolution and evolvability (talk | contribs) | Cross-wiki upload from en.wikipedia.org |
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