File:Schermatura glicana dei virus di classe I proteine di fusione.jpg

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Italiano: Schermatura glicana virali delle proteine di fusione di classe I. Da sinistra a destra: Glycan shield models of Lassa virus GPC (PDB ID: 5VK2) [ 117 , 140 ], Ebola GP (PDB ID: 5JQ3) [ 141 ], A / H3N2 / 361 / Victoria / 2011 H3N2 Influenza virus hemagglutinin (PDB ID: 4O5N) [ 142 , 143 ], BG505 SOSIP.664 HIV-1 Env (ID PDB: 4ZMJ) [ 3 , 144 ], proteina S del coronavirus umano-NL63 (HCoV-NL63) (ID PDB: 5SZS) [ 8 ] , Proteina Nipah F (ID PDB: 5EVM) [ 145]. I glicani e le proteine ​​sono mostrati rispettivamente in blu e grigio. La subunità della proteina di fusione è mostrata in grigio scuro. Le posizioni dei domini simili a mucina di Ebola GP sono mostrate in giallo. La maggior parte delle composizioni di zucchero predominanti sono state modellate su ciascun sito glicanico N-linked, utilizzando residui di GlcNAc preesistenti se possibile, con Man 5 GlcNAc 2 modellato in caso di mancanza di informazioni sulla composizione.
English: Glycan Shielding of Viral Class I Fusion Proteins. Left to right: Glycan shield models of Lassa virus GPC (PDB ID: 5VK2) [117,140], Ebola GP (PDB ID: 5JQ3) [141], A/H3N2/361/Victoria/2011 H3N2 Influenza virus hemagglutinin (PDB ID: 4O5N) [142,143], BG505 SOSIP.664 HIV-1 Env (PDB ID: 4ZMJ) [3,144], human coronavirus-NL63 (HCoV-NL63) S protein (PDB ID: 5SZS) [8], Nipah F protein (PDB ID: 5EVM) [145]. Glycans and proteins are shown in blue and grey, respectively. The fusion protein subunit is shown in dark grey. The positions of mucin-like domains of Ebola GP are shown in yellow. Most predominant sugar compositions were modelled onto each N-linked glycan site, using pre-existing GlcNAc residues if possible, with Man5GlcNAc2 modelled on if compositional information was lacking.
Date
Source Watanabe, Yasunori (2019). "Exploitation of glycosylation in enveloped virus pathobiology". Biochimica et Biophysica Acta (BBA) - General Subjects 1863 (10): 1480–1497. Elsevier BV. DOI:10.1016/j.bbagen.2019.05.012. ISSN 0304-4165.
Author

Yasunori Watanabe,un b c Thomas A. Bowden,b Ian A. Wilson,d e Max Crispinun

un School of Biological Sciences e Institute of Life Sciences, University of Southampton, Southampton SO17 1BJ, UK

b Divisione di biologia strutturale, Università di Oxford, Wellcome Centre for Human Genetics, Oxford OX3 7BN, Regno Unito

c Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, Regno Unito

d Dipartimento di Biologia Integrativa Strutturale e Computazionale, The Scripps Research Institute, La Jolla, CA 92037, USA

e Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA

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current13:25, 25 April 2021Thumbnail for version as of 13:25, 25 April 20213,573 × 1,075 (881 KB)OppidumNissenae (talk | contribs)Uploaded a work by Yasunori Watanabe un b cThomas A. Bowden bIan A. Wilson d eMax Crispin un un School of Biological Sciences e Institute of Life Sciences, University of Southampton, Southampton SO17 1BJ, UK b Divisione di biologia strutturale, Università di Oxford, Wellcome Centre for Human Genetics, Oxford OX3 7BN, Regno Unito c Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, Regno Unito d Dipartimento di Biologia Integrativ...

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