File:Schematic diagram showing the basic mechanism of the Epithelial-to-Mesenchymal Transition.jpg
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Summary[edit]
| Description | Figure 1. Schematic diagram showing the basic mechanism of the Epithelial-to-Mesenchymal Transition (EMT). Epithelial cells (A) can undergo EMT when stimulated by EMT-activators. These activators induce initial phenotypical changes (gray box) that leads to a ‘partial EMT’ state (B), in which both epithelial and mesenchymal markers are expressed. The continuous pro-EMT stimuli can ultimately cause the loss of E-cadherin thus inducing the epithelial cells to acquire a full myofibroblast phenotype (C) and ultimately the fibrotic phenotype |
| Date | |
| Source | https://www.frontiersin.org/articles/10.3389/fcell.2020.607483/full The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders. Front. Cell Dev. Biol. 8:607483. doi: 10.3389/fcell.2020.607483 |
| Author | Di Gregorio J, Robuffo I, Spalletta S, Giambuzzi G, De Iuliis V, Toniato E, Martinotti S, Conti P and Flati V |
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Copyright © 2020 Di Gregorio, Robuffo, Spalletta, Giambuzzi, De Iuliis, Toniato, Martinotti, Conti and Flati. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 12:45, 18 May 2024 | | 4,990 × 2,541 (611 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 1. Schematic diagram showing the basic mechanism of the Epithelial-to-Mesenchymal Transition (EMT). Epithelial cells (A) can undergo EMT when stimulated by EMT-activators. These activators induce initial phenotypical changes (gray box) that leads to a ‘partial EMT’ state (B), in which both epithelial and mesenchymal markers are expressed. The continuous pro-EMT stimuli can ultimately cause the loss of E-cadherin thus inducing the epithelial cells to acquire a... |
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