File:Schematic-representation-of-an-immune-response-to-a-bacterial-infection.jpg
From Wikimedia Commons, the free media repository
Jump to navigation
Jump to search
Schematic-representation-of-an-immune-response-to-a-bacterial-infection.jpg (600 × 479 pixels, file size: 190 KB, MIME type: image/jpeg)
File information
Structured data
Captions
Summary[edit]
DescriptionSchematic-representation-of-an-immune-response-to-a-bacterial-infection.jpg |
English: Schematic representation of an immune response to a bacterial infection. Tethering: P-selectins bind to PSGL-1 and tether PMN. Rolling: P-selectins bring PMN near E-selectins and slow rolling commences. Chemokine signalling: slow rolling allows IL-8 binding to CXCR1, then integrin activation results in more adhesive interactions with endothelial ligands. Adhesion: activated LFA-1 binds ICAM-1 or ICAM -2 for firm adhesion. Diapedesis: PMN begins diapedesis by exchanging tight junction molecules with endothelial cells. Migration: PMN follows a gradient of inflammatory chemokines to pathogens. Attack: complement attacks the incoming pathogens, mast cells, and macrophage phagocytose pathogens; toll-like receptor molecules trigger inflammation; antigen presenting dendritic cells express MHC molecules to activate T lymphocytes and to recruit neutrophils. PMN = polymorphonuclear neutrophil; CXCR/CCR = chemokine receptor; s-Le-x = sialyl-Lewis X; LFA = lymphocyte function-associated antigen; PSGL = P-selectin glycoprotein ligand; IL = interleukin; CD = cluster of differentiation; CD11a/CD18 = integrins; RBC = red blood cell; JAM = junctional adhesion molecule; PECAM = platelet endothelial cell adhesion molecule; DC = dendritic cell; MHC = major histocompatibility complex; T cell = T lymphocyte; IP-10 = interferon-gamma induced protein-10; MIP = macrophage inflammatory protein; RANTES = regulated on activation, normal T cell expressed and secreted (CCL5 chemokine); TNF α = tumor necrosis factor alpha; C3a and C5a = complement components 3a and 5a; LTB4 = leukotriene B4. |
Date | |
Source | Chris Tsopelas. "Radiotracers Used for the Scintigraphic Detection of Infection and Inflammation", The Scientific World Journal doi:10.1155/2015/676719 |
Author | Chris Tsopelas |
Permission (Reusing this file) |
https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
==Licensing==
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 04:23, 19 August 2019 | 600 × 479 (190 KB) | Sebastian Wallroth (talk | contribs) | Uploaded by the NOA Upload Tool |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on he.wikipedia.org