File:Rooting-the-tree-of-life-by-transition-analyses-1745-6150-1-19-4.jpg
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DescriptionRooting-the-tree-of-life-by-transition-analyses-1745-6150-1-19-4.jpg |
English: Schematic longitudinal sections through the two-tier HslV and the four-tier bacterial 20S proteasome core particle. Red dots are proteolytic active centres. Thumbnail sketches on the left of the main figure are cross sections through the proteolytic chamber showing respectively their 6-fold and 7-fold symmetry. Evolution from the 12-mer HslV to the 28-mer proteasome by duplication to form α- and β-subunits forming heptameric rings is shown by the arrow; loss of proteolytic activity by the new α-subunit (black) coupled with a new ability to stack onto the β-subunits would have expanded the digestive cavity radially and longitudinally and kept potentially vulnerable external proteins further away from the proteolytic centres. Changed dimensions and shape of the α-subunit's ATPase binding surface probably favoured replacement of the HslU ATPase ring by a different one. Hypothetical evolution in the reverse direction by loss of the α-subunit's would have created a less efficient purely β-subunit 14-mer that might have lost any ability to bind an ATPase ring through adapting to α-subunit binding instead and with a broader digestive cavity and entry pore more likely to digest the wrong proteins. It is unlikely that it could have survived purifying selection long enough to reduce its symmetry to sixfold and find a new ATPase partner to bind and thus generate HslVU. No selective advantage for simplification of a proteasome to HslV is apparent. Subunit shapes simplified from [199]. |
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Source | Image file from Cavalier-Smith T (2006). "Rooting the tree of life by transition analyses". Biology Direct. DOI:10.1186/1745-6150-1-19. | ||
Author | Cavalier-Smith T | ||
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This file is licensed under the Creative Commons Attribution 2.0 Generic license.
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current | 20:50, 13 June 2014 | 600 × 861 (89 KB) | VIAFbot (talk | contribs) | Automatic upload of media from: doi:10.1186/1745-6150-1-19 |
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