File:Regulation of EMT–MET during reprogramming.jpg
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| Description | Figure 2. Regulation of EMT–MET during reprogramming. Induced pluripotent stem cells (iPSCs) can be accelerated by sequential EMT–MET process. Early EMT can be induced by sequential expression of Yamanaka factors, adding TGF-β or inhibiting of LSD1. These treatments up-regulation of EMT-TFs and also proved metabolic switch from OXPHOS to Glycolysis (OGS). EMT and OGS coordinate to facilitate the reprogramming through an epigenetic regulation way. |
| Date | |
| Source | https://www.frontiersin.org/articles/10.3389/fcell.2020.00760/full Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming Front. Cell Dev. Biol., 06 August 2020 Sec. Molecular and Cellular Oncology Volume 8 - 2020 https://doi.org/10.3389/fcell.2020.00760 |
| Author | Lai Xiaowei, Li Qian, Wu Fang, Lin Jiechun, Chen Jiekai, Zheng Hui, Guo Lin |
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Copyright © 2020 Lai, Li, Wu, Lin, Chen, Zheng and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| current | 19:01, 15 May 2024 | | 2,651 × 1,285 (182 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 2. Regulation of EMT–MET during reprogramming. Induced pluripotent stem cells (iPSCs) can be accelerated by sequential EMT–MET process. Early EMT can be induced by sequential expression of Yamanaka factors, adding TGF-β or inhibiting of LSD1. These treatments up-regulation of EMT-TFs and also proved metabolic switch from OXPHOS to Glycolysis (OGS). EMT and OGS coordinate to facilitate the reprogramming through an epigenetic regulation way. |date=2020-08-06 |s... |
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