File:Rapid plasma reagin (RPR) Test Reactive and Non-reactive Results Demonstration for Syphilis.jpg

English: The RPR test can provide reactive (positive) or non-reactive (negative) results. Here's a demonstration of what each result may mean: Reactive (Positive) RPR Test Result-

A reactive RPR test result means that antibodies to Treponema pallidum were detected in the blood. This typically indicates a current or past syphilis infection. However, a reactive RPR test does not specify whether the infection is active (recent) or inactive (past). To further evaluate the stage and status of the infection, additional syphilis tests are usually performed, such as the-Treponemal Test- This test, such as the Fluorescent Treponemal Antibody Absorption (FTA-ABS) test or the Treponema pallidum Particle Agglutination (TP-PA) test, can confirm the presence of antibodies specific to Treponema pallidum. If both the RPR and treponemal test are positive, it suggests a current or past syphilis infection. Syphilis Stage Assessment- Additional tests and clinical evaluation may be needed to determine the stage of the syphilis infection, such as primary, secondary, latent, or tertiary syphilis. Treatment and management depend on the stage of the infection.

Non-reactive (Negative) RPR Test Result- The non-reactive RPR test result means that no antibodies to Treponema pallidum were detected in the blood at the time of testing. This result typically indicates the absence of a current syphilis infection. However, it's important to note that it can take several weeks for the body to produce detectable antibodies after initial infection. If there is a high suspicion of syphilis and recent exposure, repeat testing may be necessary after a suitable incubation period. Additionally, a non-reactive RPR result may occur in individuals who have previously been treated for syphilis and have successfully cleared the infection. In such cases, the RPR test may remain non-reactive even though the person had a previous syphilis infection.