File:Muscle-Organ Crosstalk (Myokine).jpg
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[edit]DescriptionMuscle-Organ Crosstalk (Myokine).jpg |
English: Muscle-organ crosstalk: focus on immunometabolism. Irisin and Cathepsin B enhance BDNF production and thereby hippocampal neurogenesis. IL-6 inhibits appetite and stimulates lipolysis. IL-6 also plays a role in decreasing the amount of visceral fat. IL-6, irisin and meteorin-like are involved in turning white adipose tissue into a brown phenotype. IL-15 retards skin aging. IL-6, decorin, FGF-2 and IGF-1 positively influence bone formation. Myostatin negatively influence bone formation. Musclin, LIF, IL-4, IL-6, IL-7, and IL-15 are involved in mediating muscle hypertrophy, whereas myostatin obstructs muscle hypertrophy. IL-6 and BDNF stimulate AMPK activation and hence fat oxidation. IL-6 e stimulates glucose uptake and hepatic glucose output during exercise. IL-6 induces the expression of GLP-1 by the L cells of the intestine leading to enhanced insulin secretion. IL-6 exerts anti-inflammatory effects by inhibiting TNF production and by stimulating IL-1ra and IL-10 production. IL-6 enhances cortisol production, leading to neutrocytosis and lymphopenia. FSTL-1 has beneficial effects on endothelial function and revascularization of atherosclerotic blood vessels. Osteoprotegerin, angiogenin, and IL-6 possess beta-cell protective actions against inflammatory cytokines. Adapted with permission from Severinsen and Pedersen (2020). |
Date | |
Source | https://www.frontiersin.org/articles/10.3389/fphys.2020.567881/full#B92 |
Author | Bente Pedersen |
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current | 18:33, 19 April 2023 | 1,980 × 1,850 (348 KB) | CharZakhia (talk | contribs) | Uploaded a work by Bente Pedersen from https://www.frontiersin.org/articles/10.3389/fphys.2020.567881/full#B92 with UploadWizard |
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Software used | Adobe Illustrator 24.2 (Windows) |
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File change date and time | 04:23, 25 August 2020 |
Date and time of digitizing | 17:59, 21 August 2020 |
Date metadata was last modified | 04:23, 25 August 2020 |
Unique ID of original document | xmp.did:39bea210-7a02-1549-a213-796cefefc5a5 |