File:Morphological modifications during EMT.png
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| Description | Figure 1. Morphological modifications during EMT. Epithelial cells are closely held together by different types of cell–cell junctions (i.e., adherens junctions and tight junctions) and form polarized sheets harboring an apico-basal polarity. The loss of E-cadherin (a key component of adherens junctions) is often considered the first event initiating EMT and is rapidly followed by the repression of other cell junction proteins such as zona occludens 1 (ZO-1), occludin, and claudin. Consequently, the dissolution of epithelial cell junctions elicits a loss of apico-basal polarity and triggers cytoskeletal modifications leading to the acquisition of a spindle-shaped morphology. The cells are pushed towards the EMT spectrum in a progressive and reversible manner, from a complete epithelial to complete mesenchymal state. Abbreviations: α-SMA: α-smooth muscle actin; CDH1: E-cadherin; EMT: epithelial–mesenchymal transition; FSP-1: fibroblast specific protein 1; MET: mesenchymal–epithelial transition; SNAI1: Snail family transcriptional repressor 1; TFs: transcription factors; TWIST1: twist family BHLH transcription factor 1; ZEB1: zinc finger E-box binding homeobox 1; ZO-1: zona occludens 1. |
| Date | |
| Source | https://www.mdpi.com/1422-0067/24/19/14481 Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases. Int. J. Mol. Sci. 2023, 24, 14481. https://doi.org/10.3390/ijms241914481 |
| Author | Sarrand, J.; Soyfoo, M.S. |
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© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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| current | 00:07, 17 May 2024 | | 3,297 × 2,071 (333 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 1. Morphological modifications during EMT. Epithelial cells are closely held together by different types of cell–cell junctions (i.e., adherens junctions and tight junctions) and form polarized sheets harboring an apico-basal polarity. The loss of E-cadherin (a key component of adherens junctions) is often considered the first event initiating EMT and is rapidly followed by the repression of other cell junction proteins such as zona occludens 1 (ZO-1), occlud... |
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