File:Monakow atlas.JPG

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The course of degenerated pyramidal tract fibres revealed by Marchi degeneration (marked red points in the transverse sections b, c and d). Reproduced from Monakow [22 (p. 722, figs. 171–174)]. At the time, this was the typical technique for establishing the connectivity of the motor and sensory pathway. Brain sections from a patient who suffered from a haemorrhagic insult (exitus six months later). (a) The focus of the bleeding is indicated in black at upper midbrain level. A massive interruption of descending fibres in the capsula interna entering the peduncle (quasi-horizontal section) led to their anterograde degeneration, as viewed with the Marchi procedure. (b) Transverse section at the midbrain level shows the degenerated fibres in the middle segment of the peduncle. (c) At the pontine level, descending degenerating fibres in a crescent-shaped order between islands of pontine neurons (neurons not visible with the Marchi staining). (d) Pyramid totally filled with degenerated fibres directed to the

spinal cord.
Date
Source C. von Monakow, Gehirnpathologie, A. Hölder, Vienna, 1897
Author C. von Monakow
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