File:Mechanisms of antigenic variation.jpg

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English: Mechanisms of VSG switching in T. brucei:

A. Structure of the expression site including the expression site associated genes (ESAG), 70 base pair repeat up-stream sequence, expressed VSG gene, and the telomere B. Mechanism of array VSG conversion: A silent VSG is copied from a subtelomeric VSG array into an ES, where it replaces the active VSG. C. Telomeric VSG conversion: A telomeric VSG (including 70 bp repeat sequence upstream and telomere downstream) replaces the active VSG in the ES D. Segmental VSG conversion: Sequence is copied from multiple inactive VSG genes and combined into a novel mosaic VSG that occupies the ES E. Transcriptional VSG switching: A non-recombination based mechanism that activates a new (previously silent) ES, while inactivating the previously active ES.

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Source PLoS Biology
Author Chris Stockdale, Michal R. Swiderski, J. David Barry, Richard McCulloch

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current19:27, 15 April 2011Thumbnail for version as of 19:27, 15 April 20111,914 × 984 (236 KB)2011MMG320group1 (talk | contribs){{Information |Description ={{en|1=Mechanisms of VSG switching in T. brucei: A. Structure of the expression site including the expression site associated genes (ESAG), 70 base pair repeat up-stream sequence, expressed VSG gene, and the telomere B. Mec

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