File:Kinase inactive 002.png
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Captions
Captions
The inactive conformation of cKIT kinase using x-ray crystal structure of c-Kit kinase (PDB id 1T46))
Summary[edit]
| Description |
English: (left) Ribbon diagram of the x-ray crystal structure of c-Kit kinase in complex with Imatinib (PDB id: 1T46): In the middle between the two lobes, there is the type-II inhibitor Imatinib (carbons in green). (right) Overview of the imatinib binding with (inactive/“DFG-out” conformation), highlighting regions that are relevant for small molecule inhibitor binding: A, adenine binding site/linker region; R, ribose binding region; P, phosphate binding region occupied by DFG motif; Br_I, extended back hydrophobic binding region after changing the orientation of the DFG motif; Br_II, front specificity binding region. Br_III, additional binding region in the allosteric site, used for solubilizing groups in type-II kinase inhibitors. |
| Date | |
| Source | Own work |
| Author | Chaos |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 11:20, 18 March 2024 | | 1,398 × 662 (366 KB) | Chaos (talk | contribs) | Uploaded own work with UploadWizard |
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