File:Ivermectin mechanism of action 3RHW.png

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English: Schematic diagram of the mechanism of action of ivermectin on the invertebrate glutamate-gated chloride channel receptor (GluClR), a pentameric ligand-gated ion channel. Ivermectin (IVM) interacts with a binding pocket formed by the transmembrane domains of adjacent GluClR subunits, "locking" the receptor in an activated (open) conformation that allows unrestricted passage of chloride (Cl−) ions into the cell. The plasma membrane is represented as a blue–pink gradient.
Français : Représentation schématique du mécanisme d'action de l'ivermectine sur le récepteur du "canal chlorure glutamate-dépendant" chez les invertébrés (GluClR ; un canal ionique pentamérique ligand-dépendant). L'ivermectine (IVM) interagit avec une poche de liaison formée par les domaines transmembranaires des sous-unités GluClR adjacentes, "bloquant" le récepteur dans une conformation activée (ouverte) permettant le passage sans restriction des ions chlorure (Cl-) dans la cellule. La membrane plasmique est représentée par un gradient bleu-rose.
Created using DS Studio Visualizer, PyMol (http://pymol.org), Inkscape, and GIMP.
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Source Own work, after PDB 3RHW.
Author Fvasconcellos (talk · contribs)
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current17:47, 29 November 2020Thumbnail for version as of 17:47, 29 November 20203,250 × 2,900 (2.57 MB)Fvasconcellos (talk | contribs){{Information |Description=Schematic diagram of the mechanism of action of {{w|ivermectin}} on the invertebrate glutamate-gated chloride channel receptor (GluClR), a pentameric ligand-gated ion channel. Ivermectin (IVM) interacts with a binding pocket formed by the transmembrane domains of adjacent GluClR subunits, "locking" the receptor in an activated (open) conformation that allows unrestricted passage of chloride (Cl<sup>−</sup>) ions into the cell. The plasma membrane is represented as a...

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