File:Ijms-24-11939-g006-550.webp
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Nusinersen
Summary[edit]
| Description |
English: Mechanism of action of nusinersen. Hua et al. proposed that nusinersen hampers interaction between ISS-N1 in SMN2 pre-mRNA intron 7 and hnRNP A1/A2 [106]. However, Singh et al. proposed a different mechanism. Nusinersen alters the secondary structure of SMN2 pre-mRNA, which promotes recruitment of U1 snRNP at the 5′-splice site of SMN2 pre-mRNA exon 7 |
| Date | |
| Source | https://www.mdpi.com/1422-0067/24/15/11939 |
| Author | Nishio, H.; Niba, E.T.E.; Saito, T.; Okamoto, K.; Takeshima, Y.; Awano, H. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 21:37, 18 March 2024 | | 550 × 424 (26 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Nishio, H.; Niba, E.T.E.; Saito, T.; Okamoto, K.; Takeshima, Y.; Awano, H. from https://www.mdpi.com/1422-0067/24/15/11939 with UploadWizard |
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