File:Ijms-22-08908-g004-550.jpg
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Ijms-22-08908-g004-550.jpg (550 × 383 pixels, file size: 85 KB, MIME type: image/jpeg)
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DescriptionIjms-22-08908-g004-550.jpg |
English: Figure 4. Assumed effect of muscarinic acetylcholine receptor agonists such as cevimeline on the mAChRs in association with AD. The agonist-mediated activation of mAChRs result in increased activity of PKC via same pathway as described in the previous figure. The increased activity of PKC via a cascade of reactions activates ERK, which in turn activates α-secretase. The APP is cleavaged predominantely by α-secretase to produce a non-amyloidogenic P3 peptide. In addition, the activated PKC inhibits γ-secretase activity, leading to a decrease of Aβ in the amyloidogenic pathway. Abbreviations: Aβ, amyloid beta; AICD, APP intracellular domain; APP, amyloid precursor protein; CTFα (C83), C-terminal fragment α; CTFβ (C99), C-terminal fragment β; DAG, diacylglycerol; ERK, extracellular regulated kinase; Gq/11, G proteins; IP3, inositiol trisphosphate; MEK, mitogen-activated protein kinase kinase; P3, non-amyloidogenic peptidic fragment; PIP2; phosphatidylinositol 4,5-bisphosphate; PLC, phospholipase C; PKC, protein kinase C; Raf, serine/threonine specific protein kinases; Ras, small GTP-binding proteins; sAPP/α/β, secreted APP/α/β. Created with BioRender.com. |
Date | |
Source | https://www.mdpi.com/1422-0067/22/16/8908 |
Author | Oleksak, P.; Novotny, M.; Patocka, J.; Nepovimova, E.; Hort, J.; Pavlik, J.; Klimova, B.; Valis, M.; Kuca, K. |
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 19:33, 17 March 2024 | 550 × 383 (85 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Oleksak, P.; Novotny, M.; Patocka, J.; Nepovimova, E.; Hort, J.; Pavlik, J.; Klimova, B.; Valis, M.; Kuca, K. from https://www.mdpi.com/1422-0067/22/16/8908 with UploadWizard |
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Height | 1,200 px |
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Width | 1,722 px |
Unique ID of original document | xmp.did:af5f6b7f-1fc2-4985-b88f-dd904a8d8670 |
Software used | GIMP 2.10 |
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