File:I53-50 nanoparticle vaccine schematic.png

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I53-50_nanoparticle_vaccine_schematic.png ‎(352 × 544 pixels, file size: 203 KB, MIME type: image/png)

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English: Schematic of the assembly of a I53-50 nanoparticle, a type of self-assembling protein nanoparticle designed to serve as a recombinant subunit vaccine. Three antigens form trimers (blue) that are linked to the equally trimeric building block I53-50A (grey). A I53-50 nanoparticle assembles in vitro from 20 of these antigen-I53-50A trimers and 12 I53-50B pentamers (orange). Each nanoparticle thus displays a total of 60 copies of each subunit.
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Source Derived from: Jessica Marcandalli, Brooke Fiala, Sebastian Ols, et al. (2019-03-07). "Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus". Cell 176 (6): 1420-1431.e17. DOI:10.1016/j.cell.2019.01.046. PMID 30849373. PMC: 6424820.
Author Jessica Marcandalli, Brooke Fiala, Sebastian Ols, et al.
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current11:12, 4 October 2022Thumbnail for version as of 11:12, 4 October 2022352 × 544 (203 KB)Shinryuu (talk | contribs)== {{int:filedesc}} == {{Information |Description={{en|Schematic of the assembly of a I53-50 nanoparticle, a type of {{w|Self-assembly of nanoparticles|self-assembling protein nanoparticle}} designed to serve as a recombinant {{w|subunit vaccine}}. Three {{w|antigen}}s form {{w|Protein trimer|trimer}}s (blue) that are linked to the equally trimeric building block I53-50A (grey). A I53-50 nanoparticle assembles {{w|in vitro}} from 20 of these antigen-I53-50A trimers and 12 I53-50B {{w|Pentamer...

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