File:Huntingtin-Is-Critical-Both-Pre--and-Postsynaptically-for-Long-Term-Learning-Related-Synaptic-pone.0103004.g005.jpg

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Huntingtin-Is-Critical-Both-Pre--and-Postsynaptically-for-Long-Term-Learning-Related-Synaptic-pone.0103004.g005.jpg ‎(675 × 519 pixels, file size: 72 KB, MIME type: image/jpeg)

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English: A: RNA in situ hybridization at 3 hours after oligonucleotides injection. Injection of ApHTT anti-sense oligonucleotides into the presynaptic sensory neuron lead to a decrease in ApHTT mRNA level. Confocal projection images are shown. The scale bar represents 20 µm. The summary bar graph is on the right (N = 8). B: Representative traces of EPSPs that were recorded from motor neurons in response to extracellular stimulation of sensory neurons before and 5 minutes after exposure to 1×5-HT (10 µM, 5 minutes) for STF or before and 24 hours after exposure to 5×5-HT (10 µM, 5 minutes) for LTF. C: Injection of ApHTT anti-sense oligonucleotides in the presynaptic sensory neuron has no effect on STF. D: Injection of ApHTT anti-sense oligonucleotides blocks LTF. Changes in EPSP amplitudes are shown in bar graphs. Error bars are SEM. SN: sensory neuron, MN: Motor neuron.
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Source Image file from Choi Y, Kadakkuzha B, Liu X, Akhmedov K, Kandel E, Puthanveettil S (2014). "Huntingtin Is Critical Both Pre- and Postsynaptically for Long-Term Learning-Related Synaptic Plasticity in Aplysia". PLOS ONE. DOI:10.1371/journal.pone.0103004. PMID 25054562. PMC: 4108396.
Author Choi Y, Kadakkuzha B, Liu X, Akhmedov K, Kandel E, Puthanveettil S
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current02:40, 25 July 2014Thumbnail for version as of 02:40, 25 July 2014675 × 519 (72 KB)Recitation-bot (talk | contribs)Automatic upload of media from: doi:10.1371/journal.pone.0103004

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