File:Heterotetramer of DNMTs 3A2 and 3B3 and its interactions with nucleosome and linker DNA.jpg

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Captions

Captions

DNMTs with a functioning catalytic domain require an accessory protein for methylating activity in vivo, as in the structure shown here.

Summary

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Description
English: The DNA methylating enzyme DNMT3A2, transcribed from an alternate promoter of DNMT3A1, can be active in vivo when complexed with the accessory protein DNMT3B3 in a heterotetramer structure shown here. As shown, the proximal 3B3 accessory protein interacts with a histone in the nucleosome and positions the 3A3 catalytic region of the distal 3A3 enzyme to methylate CpG sites in the adjacent linker DNA.
Date
Source Own work
Author MethylC5

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current20:20, 31 August 2023Thumbnail for version as of 20:20, 31 August 20232,110 × 1,519 (608 KB)MethylC5 (talk | contribs)Uploaded own work with UploadWizard

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