File:Hedgehog Signaling Pathway (Homo sapiens).jpg
Jump to navigation
Jump to search
Size of this preview: 638 × 600 pixels. Other resolutions: 255 × 240 pixels | 511 × 480 pixels | 1,000 × 940 pixels.
Original file (1,000 × 940 pixels, file size: 83 KB, MIME type: image/jpeg)
Captions
Captions
Hedgehog Signaling Pathway (Homo sapiens)
Summary[edit]
.jpg&action=edit§ion=1){kind=link}
| Description |
English: The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for transduction of the Hedgehog signal in vertebrates. In Hh's absence, the Ptch receptor localizes to the cilium, where it inhibits Smo activation. Gli proteins are phosphorylated by PKA, CKI and GSK3B and partially degraded into truncated Gli repressor form (GliR) that suppresses Hh target gene transcription in the nucleus. In Hh's presence, Ptch disappears from the cilium, and activated Smo contributes to the translocation of the protein complex Gli, Sufu, Kif7 to ciliary tip, where Gli dissociates from the negative regulator Sufu. The production of Gli activator form (GliA) occurs and the increased nuclear accumulation of GliA results in activation transcription of Hh target genes. Pathway adapted from KEGG |
| Date | |
| Source | https://www.wikipathways.org/index.php/Pathway:WP4249 |
| Author | Kristina Hanspers, Alexander Pico |
Licensing[edit]
.jpg&action=edit§ion=2){kind=link}
This file is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 10:39, 26 April 2019 | | 1,000 × 940 (83 KB) | Chir1UniUlm (talk | contribs) | User created page with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on en.wikipedia.org
.jpg&oldid=768331486){kind=link}