File:HSC migration from embryonic to fetal hematopoiesis..jpg
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HSC_migration_from_embryonic_to_fetal_hematopoiesis..jpg (600 × 424 pixels, file size: 89 KB, MIME type: image/jpeg)
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DescriptionHSC migration from embryonic to fetal hematopoiesis..jpg |
English: Definitive hematopoietic stem cell pools emerge from intra- (AGM) and extra- (yolk sac and placenta) embryonic hematopoietic sites. When the circulation is established and functional, HSCs start their migratory journey and colonize the placenta, followed by the fetal liver that becomes the major hematopoietic organ until the bone marrow colonized by HSCs. The adhesion molecule VE-cadherin expression has been suggested to participate in HSC/progenitor migration but there is no functional data about the molecular mediators of HSC migration in the embryo. The colonization of the fetal liver and the bone marrow are dependent on β1 integrins and the CXCL12/CXCR4 chemokine/receptor axis. |
Date | Published July 14, 2008. |
Source |
[1] Direct
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Author | Magnon, C. and Frenette, P.S., Hematopoietic stem cell trafficking (July 14, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.8.1, http://www.stembook.org. |
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This file is licensed under the Creative Commons Attribution 3.0 Unported license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 19:03, 5 April 2013 | 600 × 424 (89 KB) | Smallbot (talk | contribs) | Uploading CC-BY images from the the StemBook http://www.stembook.org/ 149/173 |
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