File:Genetic circuit approach to develop biocontainment systems 290216-A-AB123-001.jpg

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English: Genetic circuit approach to develop biocontainment systems. In the “Deadman” kill switch circuit, toxin production is repressed by LacI, which has its expression repressed by another transcriptional repressor, the Tet Repressor Protein. In a survival permissive environment, ATc is required to induce LacI expression in addition to the absence of the

LacI inducer, IPTG. Hybrid transcriptional repressors are generated by fusing environment sensing modules and DNA recognition modules from different native proteins. In these hybrids, allosteric response and DNA binding properties are defined by their ESMs and DRMs, respectively. In the “Passcode” kill switch circuit, both repressors A and B contains the LacI DRM and therefore both can repress gene C expression, which is driven by a LacI DRM-regulated Lac promoter. Gene C encodes for repressor C that is required for inhibiting toxin production. With this circuit, cell survival depends on the presence of inducers for both repressors A and B in addition to the absence of input c. All other combinations of these three inputs lead to toxin expression.

Unit: Defense Threat Reduction Agency's Chemical and Biological Technologies Department
DVIDS Tags: DNA; DRMs; LacI; biocontainment systems; biocontaintment; circut; IPTG
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Source https://www.dvidshub.net/image/2430922/genetic-circuit-approach-develop-biocontainment-systems
Author A
Location
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FORT BELVOIR, VA, US
VIRIN
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This image was released by the United States Army with the ID 290216-A-AB123-001 (next).
This tag does not indicate the copyright status of the attached work. A normal copyright tag is still required. See Commons:Licensing.

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29 February 2016, 13:31

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This file is a work of a U.S. Army soldier or employee, taken or made as part of that person's official duties. As a work of the U.S. federal government, it is in the public domain in the United States.

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current20:57, 13 March 2017Thumbnail for version as of 20:57, 13 March 20172,915 × 1,500 (255 KB)Fæ (talk | contribs)DVIDS 4 megapixel image from https://www.dvidshub.net/image/2430922/genetic-circuit-approach-develop-biocontainment-systems. DNA; DRMs; LacI; biocontainment systems. Part of User:Fæ/Project list/DoD

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