File:GE23077-binds-to-the-RNA-polymerase-i-and-i+1-sites-and-prevents-the-binding-of-initiating-elife02450fs009.jpg

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English: Superimposition of crystal structures of RPo-GE, RPo-GpA, and the transcription elongation complex: predicted steric clash between GE and NTPs in i and i+1 sites. Blue mesh, blue sticks, red sticks, gray ribbon: mFo-DFc omit map for GE, atomic model for GE, DNA template strand, and RNAP bridge helix from crystal structure of RPo-GE (Figure 4). Upper pink sticks and violet sphere: RNA 3' nucleotide in i site and Mg2+(I) from crystal structure of RPo-GpA (Zhang et al., 2012). Lower pink sticks and violet sphere: NTP in i+1 site and Mg2+(II) from crystal structure of the transcription elongation complex (Vassylyev et al., 2007).
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Source Image file from Zhang Y, Degen D, Ho M, Sineva E, Ebright K, Ebright Y, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright R (2014). "GE23077 binds to the RNA polymerase ‘i’ and ‘i+1’ sites and prevents the binding of initiating nucleotides". eLife. DOI:10.7554/eLife.02450. PMID 24755292. PMC: 3994528.
Author Zhang Y, Degen D, Ho M, Sineva E, Ebright K, Ebright Y, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright R
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current12:11, 30 July 2014Thumbnail for version as of 12:11, 30 July 2014760 × 685 (146 KB)Recitation-bot (talk | contribs)Automatic upload of media from: doi:10.7554/eLife.02450

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