File:GE23077-binds-to-the-RNA-polymerase-i-and-i+1-sites-and-prevents-the-binding-of-initiating-elife02450fs004.jpg

English: The GE target does not overlap the targets of Rif, Sor, Stl, CBR703, Myx, and Lpm. Structure of bacterial RNAP (gray ribbons; violet sphere for active-center Mg2+; β' nonconserved region and σ omitted for clarity; Mukhopadhyay et al., 2008), showing GE target (green; Figure 2C) and targets of Rif and Sor (red; Ovchinnikov et al., 1981, 1983; Lisitsyn et al., 1984; Jin and Gross, 1988; Severinov et al., 1993, 1994; Garibyan et al., 2003, Campbell et al., 2005; Xu et al., 2005; Rodriguez-Verdugo et al., 2013; ES and RHE, unpublished), Stl (yellow; Lisitsyn et al., 1985; Heisler et al., 1993; Severinov et al., 1995; Tuske et al., 2005), CBR703 (blue; Artsimovitch et al., 2003; X Wang and RHE, unpublished), Myx (magenta; Mukhopadhyay et al., 2008), and Lpm (cyan; Ebright, 2005; Srivastava et al., 2011; RY Ebright, DD, and RHE, unpublished). Views as in Figure 2C.