File:GE23077-binds-to-the-RNA-polymerase-i-and-i+1-sites-and-prevents-the-binding-of-initiating-elife02450f007.jpg
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DescriptionGE23077-binds-to-the-RNA-polymerase-i-and-i+1-sites-and-prevents-the-binding-of-initiating-elife02450f007.jpg |
English: (A) Proposed bipartite inhibitor having GE dmaDap sidechain linked to RifSV C3 or O4 atom. Crystal structure of RPo-GE-RifSV. Black line, linker. Other colors as in Figure 6H. (B) Proposed bipartite inhibitor having GE dmaDap sidechain linked to Sor sidechain carboxyl. Superimposition of crystal structures of RPo-GE and RNAP-Sor (PDB: 1YNJ). Cyan, Sor; red, residues at which substitutions confer Sor-resistance. Other colors as in A. (C) Synthesis of bipartite inhibitor having GE dmaDap sidechain linked to RifSV C3 atom (RifaGE-3). (D) Inhibition of GE-resistant RNAP ([Asp565]β-RNAP) by RifaGE-3. (E) Inhibition of Rif-resistant RNAP ([Asn516]β-RNAP) by RifaGE-3. |
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Source | Image file from Zhang Y, Degen D, Ho M, Sineva E, Ebright K, Ebright Y, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright R (2014). "GE23077 binds to the RNA polymerase ‘i’ and ‘i+1’ sites and prevents the binding of initiating nucleotides". eLife. DOI:10.7554/eLife.02450. PMID 24755292. PMC: 3994528. | |
Author | Zhang Y, Degen D, Ho M, Sineva E, Ebright K, Ebright Y, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright R | |
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This file is licensed under the Creative Commons Attribution 3.0 Unported license.
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current | 12:09, 30 July 2014 | 794 × 880 (200 KB) | Recitation-bot (talk | contribs) | Automatic upload of media from: doi:10.7554/eLife.02450 |
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Pixel composition | RGB |
Number of components | 3 |
Horizontal resolution | 600 dpi |
Vertical resolution | 600 dpi |
Color space | Uncalibrated |
Image width | 3,176 px |
Image height | 3,519 px |
Software used | Adobe Photoshop CS5 Windows |
Date and time of digitizing | 22:15, 16 April 2014 |
File change date and time | 16:13, 17 April 2014 |
Date metadata was last modified | 16:13, 17 April 2014 |
Unique ID of original document | xmp.did:3B7496F9EAC5E31189F7CF9AA92F3AE9 |
IIM version | 14 |