File:GE23077-binds-to-the-RNA-polymerase-i-and-i+1-sites-and-prevents-the-binding-of-initiating-elife02450f002.jpg

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English: (A) GER mutants obtained following saturation mutagenesis of E. coli rpoB and rpoC. (B) GER phenotype of RNAP derivatives purified from GER mutants. (C) The GE target overlaps the RNAP active-center region. Structure of RNAP (gray ribbons; black circle for active-center region; violet sphere for Mg2+(I); β’ non-conserved region and σ omitted for clarity; Mukhopadhyay et al., 2008), showing sites of GE-resistant substitutions (green; sequences from A and Supplementary file 2C). Two orthogonal views. (D) The GE target does not overlap the Rif target. Structure of RNAP, showing sites of GER substitutions (green; sequences from A and Supplementary file 2C) and RifR substitutions (red; Jin and Gross, 1988; Severinov et al., 1993). (E) GER mutants are not cross-resistant to Rif. (F) RifR mutants are not cross-resistant to GE. See Figure 2—figure supplements 1, 2.
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Source Image file from Zhang Y, Degen D, Ho M, Sineva E, Ebright K, Ebright Y, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright R (2014). "GE23077 binds to the RNA polymerase ‘i’ and ‘i+1’ sites and prevents the binding of initiating nucleotides". eLife. DOI:10.7554/eLife.02450. PMID 24755292. PMC: 3994528.
Author Zhang Y, Degen D, Ho M, Sineva E, Ebright K, Ebright Y, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright R
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