File:GE23077-binds-to-the-RNA-polymerase-i-and-i+1-sites-and-prevents-the-binding-of-initiating-elife02450f001.jpg
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DescriptionGE23077-binds-to-the-RNA-polymerase-i-and-i+1-sites-and-prevents-the-binding-of-initiating-elife02450f001.jpg |
English: (A) Structure of GE. dmaDap, Nβ-(Z-2,3-dimethylacryloyl)-α,β-diaminopropionic acid; dhGln, β,γ-dihydroxy-glutamine; Ama, aminomalonic acid; aThr, allothreonine; iSer, isoserine. Wavy bonds, previously undefined stereochemistry. (B) GE does not inhibit formation of a transcription initiation complex. (C) GE inhibits nucleotide addition in transcription initiation (primer-dependent transcription initiation). (D) GE does not inhibit nucleotide addition in transcription elongation (elongation from halted TEC containing 29 nt RNA product). See Figure 1—figure supplements 1, 2. |
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Source | Image file from Zhang Y, Degen D, Ho M, Sineva E, Ebright K, Ebright Y, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright R (2014). "GE23077 binds to the RNA polymerase ‘i’ and ‘i+1’ sites and prevents the binding of initiating nucleotides". eLife. DOI:10.7554/eLife.02450. PMID 24755292. PMC: 3994528. | |
Author | Zhang Y, Degen D, Ho M, Sineva E, Ebright K, Ebright Y, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright R | |
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This file is licensed under the Creative Commons Attribution 3.0 Unported license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 12:08, 30 July 2014 | 721 × 1,632 (135 KB) | Recitation-bot (talk | contribs) | Automatic upload of media from: doi:10.7554/eLife.02450 |
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Horizontal resolution | 600 dpi |
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Vertical resolution | 600 dpi |
Width | 1,442 px |
Height | 3,263 px |
Bits per component | 8 |
Number of components | 1 |
Image width | 1,442 px |
Image height | 3,263 px |
Color space | Uncalibrated |
Software used | Adobe Photoshop CS4 Windows |
Date and time of digitizing | 22:15, 16 April 2014 |
File change date and time | 14:50, 17 April 2014 |
Date metadata was last modified | 14:50, 17 April 2014 |
Unique ID of original document | xmp.did:5782E8C1D9C5E311AB17FD4F73A06AA3 |