File:Fonc-13-1254906-g001.jpg

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Enfortumab vedotin

Summary[edit]

Description
English: Figure 1 Mechanism of action of enfortumab vedotin (EV). (A) EV is an antibody-drug conjugate, consisting in an antibody conjugate with the cytotoxic agent Monomethyl auristatin E (MMAE). EV binds to nectin-4, which is highly expressed on urothelial cancer cells. (B) The complex is subsequently internalized into the cells via endocytosis. (C) After reaching the lysosomes, EV is degraded, allowing MMAE to be released into the intracellular district. (D) MMAE acts as a microtubules disruptor, therefore interfering with mitosis, and leading to cell apoptosis.
Date
Source https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1254906/full
Author Brigida Anna Maiorano,Martina Catalano,Evaristo Maiello,Giandomenico Roviello

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