File:Fonc-11-582664-g004.webp
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Fonc-11-582664-g004.webp (290 × 248 pixels, file size: 10 KB, MIME type: image/webp)
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DescriptionFonc-11-582664-g004.webp |
English: Figure 4 Mechanism of action of Avelumab. PD-L1 may be expressed on tumor cells and tumor-infiltrating immune cells and can contribute to the inhibition of the anti-tumor immune response in the tumor microenvironment. Binding of PD-L1 to the receptors PD-1 and B7.1 found on T cells and antigen presenting cells suppresses cytotoxic T-cell activity, T-cell proliferation and cytokine production. Avelumab binds PD-L1 through the FG loops and blocks the interaction between PD-L1 and its receptors PD-1 and B7.1. This interaction releases the inhibitory effects of PD-L1 on the immune response resulting in the restoration of immune responses, including anti-tumor immune responses. Antibody-dependent cell-mediated cytotoxicity (ADCC) response has also been found to induced by avelumab. Reprinted with permission from “Avelumab Overview - Creative Biolabs”. J Clin Invest 2015; 125: 3377-3383. Copyright © 2007 - 2019 Creative-Biolabs All Rights Reserved. |
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Source | https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.582664/full |
Author | Zhang W, Kong X, Ai B, Wang Z, Wang X, Wang N, Zheng S, Fang Y, Wang J. |
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current | 21:28, 29 March 2024 | 290 × 248 (10 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Zhang W, Kong X, Ai B, Wang Z, Wang X, Wang N, Zheng S, Fang Y, Wang J. from https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.582664/full with UploadWizard |
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