File:Fimmu-12-760199-g001.jpg

From Wikimedia Commons, the free media repository
Jump to navigation Jump to search

Original file ‎(2,126 × 1,712 pixels, file size: 218 KB, MIME type: image/jpeg)

Captions

Captions

Ruxolitinib

Summary

[edit]
Description
English: Figure 1 JAK2 inhibition in Graft-versus-Host Disease. Janus kinases are crucial to mediate extracellular signals. Binding of cytokines results in receptor dimerization and phosphorylation, subsequently phosphorylating STAT molecules by receptor tyrosine kinases. Phosphorylation of STAT leads to dimerization and translocation into the nucleus, followed by enhancing gene transcription. JAK/STAT signaling is important in regulating cell activation, proliferation, migration and effector cytokine production, thereby enhancing GvHD severity. JAK1/2 inhibition by ruxolitinib reduces pro-inflammatory signaling and cell migration, resulting in reduced GvHD disease progression. Created with Biorender.com.
Date
Source https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.760199/full
Author Lukas M. Braun,Robert Zeiser

Licensing

[edit]
w:en:Creative Commons
attribution
This file is licensed under the Creative Commons Attribution 4.0 International license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current19:59, 6 April 2024Thumbnail for version as of 19:59, 6 April 20242,126 × 1,712 (218 KB)Ozzie10aaaa (talk | contribs)Uploaded a work by Lukas M. Braun,Robert Zeiser from https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.760199/full with UploadWizard

You cannot overwrite this file.

There are no pages that use this file.

Metadata

This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.

Retrieved from "https://commons.wikimedia.org/w/index.php?title=File:Fimmu-12-760199-g001.jpg&oldid=878258331"