File:Fgene-10-00006-g002.jpg

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Roles of the CCR4-NOT complex and associated proteins in effecting 3′UTR-encoded gene regulation. The CCR4-NOT complex contains at least eight subunits, of which only six are shown here.

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English: Roles of the CCR4-NOT complex and associated proteins in effecting 3′UTR-encoded gene regulation. The CCR4-NOT complex contains at least eight subunits, of which only six are shown here. (A) Inhibition of mRNA circularization by PABP displacement and deadenylation. (B) CCR4-NOT-directed mRNA decay. The CCR4-NOT complex deadenylates the mRNA and recruits DDX6. DDX6 promotes decay through three mutually exclusive interactions, with 4E-T, EDC-3, and PAT1 (dashed lines). (C,D) Inhibition of translation through CCR4-NOT. Note that all mechanisms depicted target initiation. (C) DDX6 recruits 4E-T to prevent the binding of eIF4G to eIF4E. (D) 4EHP is recruited to the cap through 4E-T/DDX6/CCR4-NOT complex. (E) Assembly of an mRNP granule. CCR4-NOT and intrinsically disordered regions (IDRs)-encoding proteins are sequentially recruited to target mRNAs to promote mRNP formation, possibly enabling or promoting phase transition.
Date
Source Mayya VK and Duchaine TF (2019) Ciphers and Executioners: How 3′-Untranslated Regions Determine the Fate of Messenger RNAs. Front. Genet. 10:6. https://doi.org/10.3389/fgene.2019.00006
Author Vinay K. Mayya and Thomas F. Duchaine

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