File:Diagram illustrating changes in endocrine system induced by organotin and major mechanisms involved - Fendo-09-00101-g002.jpg

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Diagram illustrating changes in endocrine system induced by organotin and major mechanisms involved

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Description
English: Diagram illustrating changes in endocrine system induced by organotin and major mechanisms involved. Symbols (−) or (+) indicate inhibitory and stimulatory effects, respectively. ROS, reactive oxygen species; 5-HT, serotonine; NPY, neuropeptide Y; GnRH, gonadotropin-releasing hormone; FSH, follicle-stimulating hormone; LH, luteinizing hormone; HPG, hypothalamus–pituitary–gonad; ATP, adenosine triphosphate; NAD(P)H, nicotinamide adenine dinucleotide phosphate; 11β-HSD, 11 β-hydroxysteroid dehydrogenase; PREG, pregnenolone; 3β-HSD, 3β-hydroxysteroid dehydrogenase; P4, progesterone; E1, estrone; E2, 17-β estradiol; T, testosterone; CPY-17, 17α-hydroxylase; Adione, androstenedione; CPY-19, aromatase; 17(OH)preg, 17(OH) pregnenolone; DHEA, dehydroepiandrosterone; 5AR, 5α-reductase; DHT, dihydrotestosterone; C/EBPβ, CCAAT/enhancer binding proteins; SREBP-1c, sterol regulatory element-binding protein 1c; aP2, adipocyte-protein 2; FAS, fatty acid synthase; Fatp, fatty acid transport proteins.
Date
Source Marques VB, Faria RA and Dos Santos L (2018) Overview of the Pathophysiological Implications of Organotins on the Endocrine System. Front. Endocrinol. 9:101. doi: 10.3389/fendo.2018.00101
Author Vinicius Bermond Marques, Rodrigo Alves Faria, Leonardo Dos Santos

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