File:Deferoxamine, deferiprone, and deferasirox mechanism of action in the management of iron overload.jpg

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Deferoxamine,_deferiprone,_and_deferasirox_mechanism_of_action_in_the_management_of_iron_overload.jpg ‎(590 × 456 pixels, file size: 137 KB, MIME type: image/jpeg)

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chelation therapy

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Description
English: Deferoxamine, deferiprone, and deferasirox mechanism of action in the management of iron overload. Deferoxamine binds to nontransferrin bound iron or to iron found in ferritin forming a molecule which is later excreted via the kidneys. Deferoxamine also promotes ferritin degradation in lysosomes. Deferiprone and deferasirox chelate cytosolic labile iron. Besides, deferasirox can increase the levels of hepcidin that results in the degradation of ferroportin. TFR, transferrin receptor.
Date
Source https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098311/
Author Entezari S, Haghi SM, Norouzkhani N, Sahebnazar B, Vosoughian F, Akbarzadeh D, Islampanah M, Naghsh N, Abbasalizadeh M, Deravi N.

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current21:43, 6 May 2024Thumbnail for version as of 21:43, 6 May 2024590 × 456 (137 KB)Ozzie10aaaa (talk | contribs)Uploaded a work by Entezari S, Haghi SM, Norouzkhani N, Sahebnazar B, Vosoughian F, Akbarzadeh D, Islampanah M, Naghsh N, Abbasalizadeh M, Deravi N. from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9098311/ with UploadWizard

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