File:Death eyes.jpg
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English: The hippocampus is the brain structure responsible for memory and learning functions and it is one of the two main regions where it is possible to find newborn neurons arising from a process know as adult neurogenesis. While these newborn neurons are brought to life, mature neurons already integrated in the granular layer may die due to cell death programme mechanisms such as apoptosis and as a consequence of different stimuli. Death eyes represents this dualism in murine hippocampus. Immunofluorescence techniques have allowed to stain newborn neurons with doublecortin antibody( in blue) and an already mature neuron undergoing the apoptotic process with fraction antibody (n grey). Neuronal nuclei were stained with DAPI (red). As a result, it is possible to observe how 'dead neuron' , similar to a skull, observes with its eyes how newbor neurons come to life. Confocal microscopy. Español: El hipocampo, estructura cerebral encargada de la memoria y el aprendizaje, es una de las dos principales regiones de formación de nuevas neuronas en el cerebro, proceso conocido como neurogénesis adulta. Mientras las nuevas células se están formando, otras neuronas de la capa granular pueden llegar a morir por mecanismos programados de muerte como la apoptosis y como consecuencia de numerosos estímulos. “Los ojos de la muerte” representa esta dualidad de procesos en el hipocampo murino. Mediante técnicas de inmunofluorescencia se han teñido, de una parte, las nuevas neuronas en formación con el anticuerpo que reconoce la proteína doblecortina (azul), y por otro lado, una neurona ya madura de la capa granular que está sufriendo apoptosis con el anticuerpo anti-fractina (gris), que reconoce una fragmento escindido de la proteína actina que se produce solo en este fenómeno de muerte programada. A su vez, los núcleos celulares se tiñeron con DAPI (rojo). Como resultado, podemos observar cómo la célula apoptótica, similar a una calavera, “observa con sus ojos” el nacimiento de las nuevas neuronas. |
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| Source | Own work |
| Author | AlmudenaFM |
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This image was uploaded as part of European Science Photo Competition 2015. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 11:06, 16 November 2015 | | 1,200 × 1,200 (1.93 MB) | AlmudenaFM (talk | contribs) | User created page with UploadWizard |
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