File:Crosstalk between metabolic and epigenetic regulation.jpg
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| Description | Figure 3. Crosstalk between metabolic and epigenetic regulation. Metabolites from different metabolic pathways participate epigenetic regulation as cofactors. Dioxygenases such as HMTs and DNMTs use SAM as methyl group donor and the reverse demethylation reactions use αKG or FAD to receive the methyl groups. Acetylation of histones is achieved by HATs which transfer acetyl groups from acetyl-CoA. To remove acetyl group from histone proteins, NAD+ is used as a cofactor to support the SIRT activities which belongs to histone deacetylases (HDACs). SAM, S-adenosyl methionine; SAH, S-adenosyl homocysteine; NAD+, oxidized nicotinamide adenine dinucleotide; NAM, nicotinamide; FAD, flavin adenine dinucleotide; αKG, α-ketoglutarate; HMT, histone methyltransferase; HAT, histone acetyltransferase; and SIRT, Sirtuin. |
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| Source | https://www.frontiersin.org/articles/10.3389/fcell.2020.00760/full Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming Front. Cell Dev. Biol., 06 August 2020 Sec. Molecular and Cellular Oncology Volume 8 - 2020 https://doi.org/10.3389/fcell.2020.00760 |
| Author | Lai Xiaowei, Li Qian, Wu Fang, Lin Jiechun, Chen Jiekai, Zheng Hui, Guo Lin |
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Copyright © 2020 Lai, Li, Wu, Lin, Chen, Zheng and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 19:04, 15 May 2024 | | 2,693 × 1,277 (251 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 3. Crosstalk between metabolic and epigenetic regulation. Metabolites from different metabolic pathways participate epigenetic regulation as cofactors. Dioxygenases such as HMTs and DNMTs use SAM as methyl group donor and the reverse demethylation reactions use αKG or FAD to receive the methyl groups. Acetylation of histones is achieved by HATs which transfer acetyl groups from acetyl-CoA. To remove acetyl group from histone proteins, NAD+ is used as a cofact... |
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