File:Correlated mutation.png
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DescriptionCorrelated mutation.png |
English: Description in source: "The sequence of the protein for which the 3D structure is to be predicted (each circle is an amino acid residue, typical sequence length is 50–250 residues) is part of an evolutionarily related family of sequences (amino acid residue types in standard one-letter code) that are presumed to have essentially the same fold (iso-structural family). Evolutionary variation in the sequences is constrained by a number of requirements, including the maintenance of favorable interactions in direct residue-residue contacts (red line, right). The inverse problem of protein fold prediction from sequence addressed here exploits pair correlations in the multiple sequence alignment (left) to deduce which residue pairs are likely to be close to each other in the three-dimensional structure (right). A subset of the predicted residue contact pairs is subsequently used to fold up any protein in the family into an approximate predicted 3D shape (‘fold’) which is then refined using standard molecular physics techniques, yielding a predicted all-atom 3D structure of the protein of interest." |
Date | |
Source |
Marks et al (2011), "Protein 3D Structure Computed from Evolutionary Sequence Variation", PLoS ONE 6(12): e28766 |
Author | Debora S. Marks, Lucy J. Colwell, Robert Sheridan, Thomas A. Hopf, Andrea Pagnani, Riccardo Zecchina, Chris Sander |
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This file is licensed under the Creative Commons Attribution 2.5 Generic license.
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This file was published in a Public Library of Science journal. Their website states that the content of all PLOS journals is published under the Creative Commons Attribution 4.0 license (or its previous version depending on the publication date), unless indicated otherwise.
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current | 23:09, 15 December 2020 | 2,011 × 807 (174 KB) | Jheald (talk | contribs) | Uploaded a work by Debora S. Marks, Lucy J. Colwell, Robert Sheridan, Thomas A. Hopf, Andrea Pagnani, Riccardo Zecchina, Chris Sander from [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028766#pone-0028766-g001 "Protein 3D Structure Computed from Evolutionary Sequence Variation"], Plos One<br /> Image URL: https://journals.plos.org/plosone/article/figure/image?size=large&download=&id=10.1371/journal.pone.0028766.g001 with UploadWizard |
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