File:Conditional Dicer substrate formation via shape and sequence transduction with scRNAs.png

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English: Conditional Dicer substrate formation via shape and sequence transduction with small conditional RNAs. scRNA A·B detects mRNA detection target X (containing subsequence ‘a-b-c’), leading to production of Dicer substrate B·C targeting mRNA silencing target Y (containing independent subsequence ‘w-x-y-z’). scRNAs A·B and C are stable in the absence of X. A swaps B for X (step 1) via toehold-mediated 3-way branch migration and spontaneous dissociation. B assembles with C (step 2) via loop/toehold nucleation and 3-way branch migration to form Dicer substrate B·C. Chemical modifications (2'OMe-RNA) prevent degradation: A and part of C (dashed backbone). Image from Hochrein et al. 2013; http://pubs.acs.org/doi/abs/10.1021/ja404676x; used with permission of the American Chemical Society.
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Source http://pubs.acs.org/doi/abs/10.1021/ja404676x
Author L.M. Hochrein, M. Schwarzkopf, M. Shahgholi, P. Yin, and N.A. Pierce

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