File:Cheaper-faster-drug-development-validated-by-the-repositioning-of-drugs-against-neglected-tropical-rsif20141289-g7.jpg
Cheaper-faster-drug-development-validated-by-the-repositioning-of-drugs-against-neglected-tropical-rsif20141289-g7.jpg (674 × 513 pixels, file size: 70 KB, MIME type: image/jpeg)
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DescriptionCheaper-faster-drug-development-validated-by-the-repositioning-of-drugs-against-neglected-tropical-rsif20141289-g7.jpg |
English: Intelligent versus Random Screening. An example simulation run of intelligent screening: cycles of QSAR learning/testing from a compound library. The data are taken for a screen of the Maybridge Hitfinder library against the P. vivax DHFR as target (electronic supplementary material). Intelligent screening is red and standard brute-force black. The differential utility of intelligent screening is shown in blue. It can be seen that it is cost-optimal to screen between a third and a half of Eve's small library, with a larger library the screened proportion would be expected to be smaller. Similar diagrams for the other targets can be found in the electronic supplementary material. |
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Source | Image file from Williams K, Bilsland E, Sparkes A, Aubrey W, Young M, Soldatova L, De Grave K, Ramon J, de Clare M, Sirawaraporn W, Oliver S, King R (2015). "Cheaper faster drug development validated by the repositioning of drugs against neglected tropical diseases". Journal of the Royal Society Interface. DOI:10.1098/rsif.2014.1289. PMID 25652463. PMC: 4345494. | |
Author | Williams K, Bilsland E, Sparkes A, Aubrey W, Young M, Soldatova L, De Grave K, Ramon J, de Clare M, Sirawaraporn W, Oliver S, King R | |
Permission (Reusing this file) |
This file is licensed under the Creative Commons Attribution 4.0 International license.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 01:22, 5 July 2015 | 674 × 513 (70 KB) | Recitation-bot (talk | contribs) | Automatic upload of media from: doi:10.1098/rsif.2014.1289 |
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Horizontal resolution | 300 dpi |
Vertical resolution | 300 dpi |
Image width | 1,011 px |
Image height | 770 px |
Software used | Adobe Photoshop CS2 Windows |
Date and time of digitizing | 00:37, 4 February 2015 |
File change date and time | 00:37, 4 February 2015 |
Date metadata was last modified | 00:37, 4 February 2015 |
Unique ID of original document | uuid:7FDD255B2746E01196BCCF73A6F2B031 |
IIM version | 2 |