File:Cell morphology and mechanics are vimentin dependent.jpg
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| Description | Figure 4. Cell morphology and mechanics are vimentin dependent. a Epithelial breast cancer cells (MCF-7) that only express keratin are initially compact and rounded. b After microinjection of recombinant vimentin, cells adopt an elongated, mesenchymal-like morphology, with c immunofluorescence staining (vimentin). Reproduced from [93]. d Optical tweezer measurements manipulate embedded tracer particle to probe local cytoskeletal mechanics. e Increasing vimentin expression in mouse embryonic fibroblasts increases mechanical deformability before yielding. Abbreviations denote vimentin knockout (Vim –/–), decellularized vimentin (“ghost cell”) with all other cellular components removed, wildtype (WT), and vimentin overexpression (OverE). |
| Date | |
| Source | https://biosignaling.biomedcentral.com/articles/10.1186/s12964-021-00713-2#rightslink The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems. Cell Commun Signal 19, 32 (2021). https://doi.org/10.1186/s12964-021-00713-2 |
| Author | Leggett, S.E., Hruska, A.M., Guo, M. et al. |
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| current | 20:48, 16 May 2024 | | 1,612 × 1,150 (748 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 4. Cell morphology and mechanics are vimentin dependent. a Epithelial breast cancer cells (MCF-7) that only express keratin are initially compact and rounded. b After microinjection of recombinant vimentin, cells adopt an elongated, mesenchymal-like morphology, with c immunofluorescence staining (vimentin). Reproduced from [93]. d Optical tweezer measurements manipulate embedded tracer particle to probe local cytoskeletal mechanics. e Increasing vimentin expr... |
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