File:Antibiotics-12-00760-g003.jpg
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Phentolamine
Summary[edit]
| Description |
English: Proposed phentolamine mechanism of action. Phentolamine uncouples the electron transport chain, dissipates the PMF, and decreases ATP production to inhibit TolC-mediated efflux activity. Phentolamine also damages the outer membrane, and these activities enhanced ERY entry that could not be reversed by efflux pump activation. The sum of these effects are increased levels of macrolide potency against Gram-negative bacteria. |
| Date | |
| Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135019/ |
| Author | Cui ZH, He HL, Zheng ZJ, Yuan ZQ, Chen Y, Huang XY, Ren H, Zhou YF, Zhao DH, Fang LX, Yu Y, Liu YH, Liao XP, Sun J. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 20:51, 18 March 2024 | | 784 × 508 (114 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Cui ZH, He HL, Zheng ZJ, Yuan ZQ, Chen Y, Huang XY, Ren H, Zhou YF, Zhao DH, Fang LX, Yu Y, Liu YH, Liao XP, Sun J. from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135019/ with UploadWizard |
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