File:Adenosine Receptors Down-Regulate Inflammation through a Negative Feedback Loop.png

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English: Sitkovsky and colleagues postulate that inflammation causes tissue damage leading to adenosine release, which acts on adenosine A2ARs to increase intracellular cyclic AMP. The rise in cyclic AMP down-regulates the inflammatory response. Tissue inflammation induces local hypoxia, which regulates the adenosine-driven protective response. The figure shows the steps in the pathway where hyperoxia might act (having an inhibitory effect).
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Source doi:10.1371/journal.pmed.0020130
Author Public Library of Science
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