File:Accuracy of universal methylation aging clocks are independent of species lifespan.webp
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[edit]DescriptionAccuracy of universal methylation aging clocks are independent of species lifespan.webp |
English: "The circle plot displays Pearson correlation between age and DNAmAge estimated by universal clocks 2 (clock 2) and 3 (clock 3) for various species. Of the 185 species, correlation analysis was performed on 69 species (with n ≥ 15 in a single tissue) across 12 taxonomic orders. We took log transformation of maximum lifespans of species and divided them by log (211), which is the maximum lifespan of bowhead whales. Values of the resulting ratios ranged from 0.12 (cinereus shrew) to 1 (bowhead whales). These ratios are displayed in descending order in the circle plot marked by the black dashed line, starting with the bowhead whale (1) and human (0.90) and ending with the cinereus shrew (0.12), in counterclockwise direction. In the background, circumferences with increasing radii represent increasing correlation levels up to 0.9. These correlations between age and DNAmAge were estimated by clock 2 (red path line) and clock 3 (purple path line) for each species. Colors within the circle represent the taxonomic order of the corresponding species, as listed below the circle. The median of correlation across species is 0.926 for clock 2 and 0.918 for clock 3. Straw-colored fruit bats exhibit the highest correlation (r = 0.985) based on clock 2, and Wisconsin miniature pigs have the second highest correlation (r = 0.984) based on clock 3. A majority of species with their circle lines located outside the background indicates that their correlation estimates are greater than 0.9. The text at the bottom lists the 185 species under their corresponding taxonomic order. Each taxonomic order is marked by the same color matching with the circle plot. The numbers after the first and second decimal points enumerate the taxonomic family and species, respectively. AU, Australian; Comme., Commerson’s; E., eastern; f.t., free-tailed; g.m., golden-mantled; H. (gazelle), Horn gazelle; Hoff., Hoffman’s; IP, Indo-Pacific; L.’s, Linne’s; l.n., long-nosed; m.e., mouse-eared; mini., miniature; N., northern; o.h., one horned; s.c., small-clawed; PAC w.s., Pacific white-sided; R.-toothed, Rough-toothed; Soemm., Soemmerring’s; S.finn., Short-finned; s.n., short nosed; s.t., short-tailed; s.w., sac-winged; W. western; W.F., White-fronted; WI mini., Wisconsin miniature." |
Date | |
Source | https://www.nature.com/articles/s43587-023-00462-6 |
Author | Authors of the study: A. T. Lu, Z. Fei, A. Haghani, T. R. Robeck, J. A. Zoller, C. Z. Li, R. Lowe, Q. Yan, J. Zhang, H. Vu, J. Ablaeva, V. A. Acosta-Rodriguez, D. M. Adams, J. Almunia, A. Aloysius, R. Ardehali, A. Arneson, C. S. Baker, G. Banks, K. Belov, N. C. Bennett, P. Black, D. T. Blumstein, E. K. Bors, C. E. Breeze, R. T. Brooke, J. L. Brown, G. G. Carter, A. Caulton, J. M. Cavin, L. Chakrabarti, I. Chatzistamou, H. Chen, K. Cheng, P. Chiavellini, O. W. Choi, S. M. Clarke, L. N. Cooper, M. L. Cossette, J. Day, J. DeYoung, S. DiRocco, C. Dold, E. E. Ehmke, C. K. Emmons, S. Emmrich, E. Erbay, C. Erlacher-Reid, C. G. Faulkes, S. H. Ferguson, C. J. Finno, J. E. Flower, J. M. Gaillard, E. Garde, L. Gerber, V. N. Gladyshev, V. Gorbunova, R. G. Goya, M. J. Grant, C. B. Green, E. N. Hales, M. B. Hanson, D. W. Hart, M. Haulena, K. Herrick, A. N. Hogan, C. J. Hogg, T. A. Hore, T. Huang, J. C. Izpisua Belmonte, A. J. Jasinska, G. Jones, E. Jourdain, O. Kashpur, H. Katcher, E. Katsumata, V. Kaza, H. Kiaris, M. S. Kobor, P. Kordowitzki, W. R. Koski, M. Krützen, S. B. Kwon, B. Larison, S. G. Lee, M. Lehmann, J. F. Lemaitre, A. J. Levine, C. Li, X. Li, A. R. Lim, D. T. S. Lin, D. M. Lindemann, T. J. Little, N. Macoretta, D. Maddox, C. O. Matkin, J. A. Mattison, M. McClure, J. Mergl, J. J. Meudt, G. A. Montano, K. Mozhui, J. Munshi-South, A. Naderi, M. Nagy, P. Narayan, P. W. Nathanielsz, N. B. Nguyen, C. Niehrs, J. K. O’Brien, P. O’Tierney Ginn, D. T. Odom, A. G. Ophir, S. Osborn, E. A. Ostrander, K. M. Parsons, K. C. Paul, M. Pellegrini, K. J. Peters, A. B. Pedersen, J. L. Petersen, D. W. Pietersen, G. M. Pinho, J. Plassais, J. R. Poganik, N. A. Prado, P. Reddy, B. Rey, B. R. Ritz, J. Robbins, M. Rodriguez, J. Russell, E. Rydkina, L. L. Sailer, A. B. Salmon, A. Sanghavi, K. M. Schachtschneider, D. Schmitt, T. Schmitt, L. Schomacher, L. B. Schook, K. E. Sears, A. W. Seifert, A. Seluanov, A. B. A. Shafer, D. Shanmuganayagam, A. V. Shindyapina, M. Simmons, K. Singh, I. Sinha, J. Slone, R. G. Snell, E. Soltanmaohammadi, M. L. Spangler, M. C. Spriggs, L. Staggs, N. Stedman, K. J. Steinman, D. T. Stewart, V. J. Sugrue, B. Szladovits, J. S. Takahashi, M. Takasugi, E. C. Teeling, M. J. Thompson, B. Van Bonn, S. C. Vernes, D. Villar, H. V. Vinters, M. C. Wallingford, N. Wang, R. K. Wayne, G. S. Wilkinson, C. K. Williams, R. W. Williams, X. W. Yang, M. Yao, B. G. Young, B. Zhang, Z. Zhang, P. Zhao, Y. Zhao, W. Zhou, J. Zimmermann, J. Ernst, K. Raj & S. Horvath |
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 11:59, 15 October 2023 | 2,037 × 2,597 (713 KB) | Prototyperspective (talk | contribs) | Uploaded a work by Authors of the study: A. T. Lu, Z. Fei, A. Haghani, T. R. Robeck, J. A. Zoller, C. Z. Li, R. Lowe, Q. Yan, J. Zhang, H. Vu, J. Ablaeva, V. A. Acosta-Rodriguez, D. M. Adams, J. Almunia, A. Aloysius, R. Ardehali, A. Arneson, C. S. Baker, G. Banks, K. Belov, N. C. Bennett, P. Black, D. T. Blumstein, E. K. Bors, C. E. Breeze, R. T. Brooke, J. L. Brown, G. G. Carter, A. Caulton, J. M. Cavin, L. Chakrabarti, I. Chatzistamou, H. Chen, K. Cheng, P. Chiavellini, O. W. Choi, S. M. Cl... |
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