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progressive multifocal leukoencephalopathy
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| Description |
English: Development of progressive multifocal leukoencephalopathy during natalizumab treatment. This figure summarizes the three hypotheses on how natalizumab may lead to PML. (a) Natalizumab may prevent the entry of JCV-specific cytotoxic T cells into the brain, necessary for the control of latent JCV within infected oligodendrocytes. (b) Natalizumab inhibits the VLA-4-dependent homing and retentions of lymphocytes in bone marrow (sites of JCV latency), thus leading to an increase of JCV-infected peripheral leukocytes. Finally, another possible factor is the natalizumab-induced expression of Spi-B, a transcription factor that has been shown to increase JCV transcription. |
| Date | |
| Source | https://www.hindawi.com/journals/jir/2013/967581/ |
| Author | Diotti RA, Nakanishi A, Clementi N, Mancini N, Criscuolo E, Solforosi L, Clementi M. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 21:53, 30 March 2024 | | 600 × 497 (90 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Diotti RA, Nakanishi A, Clementi N, Mancini N, Criscuolo E, Solforosi L, Clementi M. from https://www.hindawi.com/journals/jir/2013/967581/ with UploadWizard |
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