File:Zebra fish U0126 produces a specific and consistent phenotype affecting pigmentation and notochord development.jpeg
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[edit]DescriptionZebra fish U0126 produces a specific and consistent phenotype affecting pigmentation and notochord development.jpeg | Zebra fish. U0126 produces a specific and consistent phenotype affecting pigmentation and notochord development. Phenotype of wild type and U0126-treated embryos at 24 hpf. (A-F) and at 48 hpf (G-L). There is a total lack of pigmentation including in the RPE in the eye (compare panels I and L), twists and undulations in the NC are already evident at 24 hpf. (D, E) and the trunk and tail of treated embryos is shortened at 48 hpf (compare panels G and J). The large yolk sac in 48 hpf embryos indicates that circulation is not established properly to carry away its content (see also later in Fig. 5) Panels A-C, G-I: wild type embryos. Panels D-F, J-L: U0126-treated embryos. |
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Source | https://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-213X-8-42#Fig2 https://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-213X-8-42 Hawkins, T.A., Cavodeassi, F., Erdélyi, F. et al. The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish. BMC Dev Biol 8, 42 (2008). |
Author | Hawkins, T.A., Cavodeassi, F., Erdélyi, F. et al. |
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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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current | 00:24, 25 April 2024 | 1,890 × 1,890 (1.18 MB) | Rasbak (talk | contribs) | {{Information |description=Zebra fish. U0126 produces a specific and consistent phenotype affecting pigmentation and notochord development. Phenotype of wild type and U0126-treated embryos at 24 hpf. (A-F) and at 48 hpf (G-L). There is a total lack of pigmentation including in the RPE in the eye (compare panels I and L), twists and undulations in the NC are already evident at 24 hpf. (D, E) and the trunk and tail of treated embryos is shortened at 48 hpf (compare panels G and J). The large yo... |
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