File:Whole genome shotgun sequencing versus Hierarchical shotgun sequencing.png

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English: In whole genome shotgun sequencing (top), the entire genome is sheared randomly into small fragments (appropriately sized for sequencing) and then reassembled. In hierarchical shotgun sequencing (bottom), the genome is first broken into larger segments. After the order of these segments is deduced, they are further sheared into fragments appropriately sized for sequencing.
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Source "Computational Biology Methods and Their Application to the Comparative Genomics of Endocellular Symbiotic Bacteria of Insects." Biol. Procedures Online (2009). Accessed via SpringerImages.
Author Commins, J., Toft, C., Fares, M. A.


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