File:Viruses-07-02837-g003.png
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Captions
Captions
Comparison of full-length NS5 structures from JEV and DENV.
Summary
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| Description |
English: Comparison of full-length NS5 structures from JEV and DENV. Overall fold of JEV and DENV full-length NS5 (Protein Data Bank entries 4K6M and 4VOQ) are shown from the canonical right hand view of RdRp (top) and side view (bottom). Side views of both monomer and dimer forms of DENV NS5 are shown. The RdRp domain consists of fingers (green), palm (blue), and thumb (red) subdomains. The MTase domain (cyan) sits opposite the dsRNA exit channel of the RdRp and near the template-binding channel. The methyl donor used during MTase reaction, AdoMet, is shown in yellow. In each structure, the same region of the RdRp contacts the MTase. The MTase residues at the domain interface from JEV and DENV are indicated by pink and orange spheres, respectively. For comparison, corresponding residues are also mapped on the structures. Domain interactions are also indicated in schematics by a series of three lines below the side view. The MTase active site is indicated by dashed ovals, and the RdRp template channel is shown as a dashed tube. |
| Date | |
| Source |
Klema, V.J.; Padmanabhan, R.; Choi, K.H. Flaviviral Replication Complex: Coordination between RNA Synthesis and 5’-RNA Capping. Viruses 2015, 7, 4640-4656. https://www.mdpi.com/1999-4915/7/8/2837/htm |
| Author | Valerie J. Klema, Radhakrishnan Padmanabhan, and Kyung H. Choi |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 10:21, 26 November 2020 | | 2,421 × 2,207 (2.78 MB) | Guest2625 (talk | contribs) | Uploaded a work by Valerie J. Klema, Radhakrishnan Padmanabhan, and Kyung H. Choi from Klema, V.J.; Padmanabhan, R.; Choi, K.H. Flaviviral Replication Complex: Coordination between RNA Synthesis and 5’-RNA Capping. Viruses 2015, 7, 4640-4656. https://www.mdpi.com/1999-4915/7/8/2837/htm with UploadWizard |
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