File:Viruses-07-02832-g006.png
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Captions
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Morphogenesis of enteroviruses and targets for assembly inhibitors.
Summary
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| Description |
English: Morphogenesis of enteroviruses and targets for assembly inhibitors. Hsp90 ensures the proper folding of the P1 precursor protein enabling the cleavage by 3CDpro into capsid proteins VP0, VP3, and VP1 which then form protomers. For part of the EVs, glutathione (GSH) is required either for the transition of protomers into pentamers or for the stabilization of pentamers. Twelve pentamers plus the viral genome (in red) combine to form a provirion, followed by a maturation step in which the VP0 protein is cleaved into VP4 and VP2. Treatment with Hsp90 inhibitors or glutathione depletors results in impaired morphogenesis. |
| Date | |
| Source | https://www.mdpi.com/1999-4915/7/8/2832/htm |
| Author | Lonneke Van der Linden, Katja C. Wolthers, and Frank J.M. Van Kuppeveld |
Licensing
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This file is licensed under the Creative Commons Attribution 4.0 International license.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 09:32, 3 September 2020 | | 3,632 × 1,945 (647 KB) | Guest2625 (talk | contribs) | Uploaded a work by Lonneke Van der Linden, Katja C. Wolthers, and Frank J.M. Van Kuppeveld from https://www.mdpi.com/1999-4915/7/8/2832/htm with UploadWizard |
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