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English: Contributors to levels of representative sulfated sex hormones. Multivariate linear regression model of (Panel A) pregnen-diol disulfate levels and (Panel B) 5alpha-androstan-3beta,17beta-diol disulfate levels. Shown are the beta values from an analysis of visit 1 metabolite levels versus covariates in 872 unrelated individuals of European ancestry. To make the scaling consistent, age, the first principal component of European-specific EIGENSTRAT axes (PC1), body mass index, and genotype have been transformed to a scale from 0 to 1. Decreased levels of these metabolites are found in those with increased age, those who are taking acetaminophen, females, and carriers of the (minor) C allele of SULT2A1 variant rs2547237. Decreased levels of 5alpha-androstan-3beta,17beta-diol disulfate are also found in carriers of the G (minor) allele of CYP3A7-CYP3A51P variant rs45446698, but this variant did not impact pregnen-diol disulfate levels. Here, all variables whose confidence intervals do not cross the dotted 0 line have p < 0.0005. Also shown are the levels (Panel C) of pregnen-diol disulfate and (Panel D) 5alpha-androstan-3beta,17beta-diol disulfate at visit 1, broken down by rs2547237 and rs45446698 genotype, sex, acetaminophen use, and age.