File:The metastatic cascade (01).jpg
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| Description | Figure 1 The metastatic cascade. Epithelial tumours may sometimes undergo EMT to generate mesenchymal cells with more motile and invasive properties that penetrate the basal lamina (invasion [1]) and enter the bloodstream or lymphatic system, becoming circulating tumour cells (intravasation [2]), which are transported via the systemic circulation (circulation [3]), migrate into distant tissues that have the favourable cellular cues (extravasation [4]). The microenvironmental signals then induce an EMT reversal (also called MET) to establish secondary micrometastases |
| Date | |
| Source | https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.762817/full Understanding the Complex Milieu of Epithelial-Mesenchymal Transition in Cancer Metastasis: New Insight Into the Roles of Transcription Factors. Front. Oncol. 11:762817. doi: 10.3389/fonc.2021.762817 |
| Author | Imodoye SO, Adedokun KA, Muhammed AO, Bello IO, Muhibi MA, Oduola T and Oyenike MA |
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Copyright © 2021 Imodoye, Adedokun, Muhammed, Bello, Muhibi, Oduola and Oyenike. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| current | 10:04, 19 May 2024 | | 2,815 × 1,668 (432 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 1 The metastatic cascade. Epithelial tumours may sometimes undergo EMT to generate mesenchymal cells with more motile and invasive properties that penetrate the basal lamina (invasion [1]) and enter the bloodstream or lymphatic system, becoming circulating tumour cells (intravasation [2]), which are transported via the systemic circulation (circulation [3]), migrate into distant tissues that have the favourable cellular cues (extravasation [4]). The microenvi... |
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