File:The mechanisms of action of some common chemotherapeutic drugs.png

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Description FIGURE 1 The mechanisms of action of some common chemotherapeutic drugs. The main mechanisms are forming DNA crosslinks (cisplatin, carboplatin), disrupting topoisomerase-II-mediated DNA repair (doxorubicin), promote microtubule polymerization and stabilization (paclitaxel, docetaxel), binding to the minor groove of DNA (trabectedin), inhibiting thymidylate synthase (5-fluorouracil), antimetabolite for pyrimidine nucleoside (gemcitabine) (Larionova et al., 2019)
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Source https://www.researchgate.net/publication/349921267_Extracellular_Vesicle-Mediated_Chemoresistance_in_Oral_Squamous_Cell_Carcinoma Extracellular Vesicle-Mediated Chemoresistance in Oral Squamous Cell Carcinoma. Front. Mol. Biosci. 8:629888. doi:10.3389/fmolb.2021.629888 Frontiers in Molecular Biosciences www.frontiersin.org March 2021 Volume 8 Article 6298881 REVIEW doi: 10.3389/fmolb.2021.629888
Author Law ZJ, Khoo XH, Lim PT, Goh BH, Ming LC, Lee WL and Goh HP
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current21:05, 15 May 2024Thumbnail for version as of 21:05, 15 May 20241,562 × 930 (707 KB)Rasbak (talk | contribs){{Information |description=FIGURE 1 The mechanisms of action of some common chemotherapeutic drugs. The main mechanisms are forming DNA crosslinks (cisplatin, carboplatin), disrupting topoisomerase-II-mediated DNA repair (doxorubicin), promote microtubule polymerization and stabilization (paclitaxel, docetaxel), binding to the minor groove of DNA (trabectedin), inhibiting thymidylate synthase (5-fluorouracil), antimetabolite for pyrimidine nucleoside (gemcitabine) (Larionova et al., 2019) |dat...

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